This astrocyteneuron lactate shuttle (ANLS), initially hypothesized by Pellerin and Magistretti, holds that BBB cells take up blood glucose via astrocytic/endothelial GLUT1 transport, allowing cerebral lactate buffering by astrocytic glycogen stores [56]
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10.4103/0253-7613.178834 61 LiS.CaoC.ShiH.YangS.QiL.ZhaoX.et al (2016b)
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Since the cuprizone regimen was several times higher than those regularly used in cuprizone studies, we used simple tests to determine animal responsiveness and impairment
Some used endothelial cells, some used tendon-derived fibroblasts, and others used isolated tissues or laboratory animal models