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This cascade stimulates robust dendritic spinogenesis and new functional synaptogenesis in neuronal models, demonstrating neurotrophic potency up to seven orders of magnitude greater than Brain-Derived Neurotrophic Factor (BDNF)

They reflect deeper biological systemsbarrier integrity, hydration dynamics, lipid balance, and structural protein turnoverworking in coordination

They mimic the action of endogenous GLP-1, a hormone naturally released by cells in the small intestine in response to food intake and exert effects 16 (Figure 1) in a dose-dependent manner 17

the disease is considered to be the manifestation of a local Th1-dependant granulomatous inflammation