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Human GIP(3-30)NH 2 inhibits G protein-dependent as well as G protein-independent signaling and is selective for the GIP receptor with high-affinity binding to primate but not rodent GIP receptors

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This stabilizes blood glucose and reduces the metabolic shock that can trigger headaches

An accompanying editorial to the study noted that if the benefit is cumulative, adding roughly three motor-score points of protection per year over 5-10 years, then this class of drugs could prove transformative for a disease that currently has few disease-modifying interventions

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