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These agents demonstrate remarkable efficacy through both direct hepatic effects and indirect metabolic improvements

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While its primary role is to help the pancreas release the right amount of insulin, it also has a significant effect on the digestive system

This process is called titration, which means adjusting the dose in planned steps

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Para resolver esse desafio, a estratgia adotada foi manter a estrutura peptdica semelhante a liraglutida e ao GLP-1 endgeno, com uma modificao apenas na posio 8, substituindo Ala por Aib, conhecido por resistir clivagem pelo DPP-IV e ter alta afinidade pelo GLP-1R