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[5] GHS-R1a receptors are expressed not only on pituitary somatotrophs but also in the hypothalamic arcuate nucleus, where they are co-localized with neurons involved in reproductive hormone regulation

These observations create a plausible mechanistic pathway in PCOS: metabolic and hormonal perturbations (hyperandrogenism, insulin resistance) promote platelet hyperreactivity and PMP release, which in turn primes neutrophils to NETose within adipose, ovarian, and vascular beds

It functions primarily as a master antioxidant that reduces oxidative stress, detoxifies the body, and shifts melanin production from darker eumelanin to lighter pheomelanin

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doi: 10.1016/j.tice.2021.101621 41 IgnacioBJAlbinTJEsser-KahnAPVerdoesM