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In dermal fibroblasts and ex-vivo skin, combining GHK-Cu with low-molecular-weight HA synergistically boosted collagen I/IV/VII, with collagen IV up 25.4 in cells and ~2 in ex-vivo skin, supporting topical maintenance after systemic cycles

This underscores the importance of considering both ECM protein composition and mechanical properties in future studies, as the interplay between these factors significantly influences how cells interpret and respond to mechanical signals, thereby affecting cellular function and differentiation pathways