Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that has transformed the treatment of type 2 diabetes and obesity
Retatrutide pros Triple mechanism of action : Retatrutide targets GLP-1, GIP, and GCG, which could offer a more comprehensive approach to weight loss, blood sugar control, and metabolic health, potentially providing superior benefits over dual agonists like tirzepatide
These data emphasise the importance of accessible and affordable long-term structured lifestyle modification programmes, including diet, physical activity, and behavioural therapy, for individuals with MASLD, and highlight the need for longer-term (2 years) RCTs on lifestyle interventions
This is not the drug failing
It has a strong safety record and is widely used in clinical practice
Menstrual cycle changes Menstrual disruption is among the most commonly reported female-specific effects of GLP-1 agonists as a class