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If you talk about a class of medicine where small molecules, they can be different, but they're usually more alike than they're different

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Specifically, mutagenesis of ECD, ECL1 and ECL3 individually increased the basal activity of GCGR, which could result from the interruption of intramolecular interactions between the ECD and ECL1/3 that otherwise stabilize the receptor in an inactive state

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