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Nat Immunol
Other animal studies examined the specific molecular pathway involved in exendin-4s immune-suppressive effect
Tirzepatide, a dual GIP/GLP-1 receptor co-agonist, also demonstrated significant efficacy in a phase II trial for MASH [6]
The mechanistic explanation is not speculative: the glucagon receptor adds hepatic fatty-acid oxidation, adipose lipolysis and thermogenic energy expenditure that dual agonism cannot engage by design 27, and the Phase 2a MASLD readouts 8590% liver-fat reduction is a direct signature of that pathway 3
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