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The purpose of RT is to minimize the damage to normal tissues in the environment while giving a cytotoxic dose to the tumor.[] RT-induced pneumonitis is one of the most serious dose-limiting toxicities in patients receiving thoracic RT for lung cancer

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The small hydrophilic molecules include glucuronic acid, glutathione, sulfate, amino acids, and a methyl group, which are catalyzed by glucuronyl transferases, glutathione transferases, sulfotransferases, amino acid transferases, and N- and O-methyltransferases, respectively [21]

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