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There were 2 large human trials with 117 and 320 patients each, but neither showed any benefits after 7-10 days of administration

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Our findings of increased serum palmitoyl-L-carnitine with aging are consistent with observations in heart failure and coronary artery disease [56], where elevated levels likely result from disrupted mitochondrial fatty acid oxidation and impaired -oxidation, leading to acylcarnitine accumulation [57]

There are trade-offs, of course