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New research shows GLP-1 drugs can help reduce pain and improve mobility, sometimes more than SGLT2 inhibitors
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Long-term treatment with palmitate, a type of long-chain saturated fatty acid, can disrupt the rhythmic secretion of GLP-1 by suppressing the expression of the Bmal1 clock gene [141]
GLP-1s and Addiction The authors of GLP-1 Therapeutics and Their Emerging Role in Alcohol and Substance Use Disorders: An Endocrinology Primer , appearing in October 2025 in JES, point out that the World Health Organization reported 890 million adults and 60 million children and adolescents had obesity in 2022 globally
