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The fourth row in Table 4 requires more comment

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doi: 10.1016/j.cell.2015.09.020 111 SinghRKaushikSWangYXiangYNovakIKomatsuMet al

MT-II was designed and characterised through the systematic melanocortin peptide structure-activity relationship programme in Victor Hrubys laboratory at the University of Arizona , the same programme that produced MT-1 , with the cyclisation strategy introduced to further constrain the pharmacophore into a receptor-binding conformation that simultaneously increases potency, metabolic stability, and the receptor subtype selectivity profile that distinguishes MT-II from the linear tridecapeptide MT-1