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Featuring a quinoline ring as its core scaffold, it has a small molecular weight and excellent cell membrane permeability

The concept that binding proteins existed for peptide hormones like the IGFs, similar to those for steroid and thyroid hormones, were suggested by studies from Zapf and Froesch (12) and by Hintz (13), demonstrating that NSILA was present in high molecular weight complexes in serum

Red dotted lines indicate hydrogen bonds