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(4) The phylum Actinobacteria includes numerous beneficial gut bacteria, such as Bifidobacterium and Collinsella , which modulate the immune system, improve gut barrier function, and reduce inflammation ( 3.3 Gut microbiota metabolites Gut microbiota-dependent metabolites act as a bridge that connects the dynamic equilibrium between the host and the gut microbiota (Schoeler et al., 2019)