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In GLP-1-infused subjects, plasma levels of GLP-1 rose from ~ 19 pM to 197 pM by week 1, and 282 pM at week 6

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The glucagon component likely drives this through increased hepatic fat oxidation

How Retatrutide Works (Mechanism of Action) In biochemical and preclinical research models, retatrutide interacts with three class B G protein coupled receptors that participate in metabolic signaling networks: the glucagon like peptide 1 receptor (GLP 1R), the glucose dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)

2 Since it is non-peptide, orforglipron avoids GI degradation barriers that limit peptides, thereby enabling once-daily administration while maintaining efficacy on glucose control, body weight, and tolerability