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Acknowledgements This study was approved by the Alfred Hospital Ethics Committee (project number 463/18) and the Australian Institute of Health and Welfare Ethics Committee (EO2018/5/501)

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Improving Functional Pathways for Weight Management Enhancement of Beneficial Pathways: The study identified increased pathways related to SCFA production and the degradation of simple sugars

Tirzepatide acts on dual hormone receptors in the body for weight and diabetes management

For weight management specifically, Wegovy (semaglutide 2.4 mg) is the licensed formulation in the UK, available under NICE guidance (TA875)

Neutrophil elastase and chronic lung disease