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10.1124/jpet.114.218735 15 BenoistC

Nutrients 9 , 1239 (2017)

To meet the diagnostic criteria for cEDS, a person must meet: Major criterion 1 AND major criterion 2 OR Major criterion 1 AND three or more minor criteria Major Criteria Skin hyperextensibility and atrophic scarring Generalized joint hypermobility Minor Criteria Easy bruising Soft, doughy skin Skin fragility (or traumatic splitting) Molluscoid pseudotumors Subcutaneous spheroids Hernia (or history thereof) Epicanthal folds Complications of joint hypermobility (e.g., sprains, dislocations/subluxations, pain, flexible flatfoot) Family history of a first-degree relative who meets clinical criteria Genetic testing is used to see if a person has a genetic variant that causes vEDS

Elevated LPS in hepatocytes promoted the expression of SREBP2 by activating TLR4-Myd88 and the relative inflammatory response pathway (JNK/c-Jun) (108, 109)

Labs should implement clear protocols for storage areas, including temperature monitoring and regular checks for environmental consistency

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