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Para el manejo del peso, los estudios clnicos han demostrado prdidas promedio del 15% del peso corporal inicial con semaglutida 2.4 mg (Wegovy) y hasta 20% con tirzepatida (Zepbound) en algunos pacientes

Enriched upregulated gene sets for pre-obese mice were associated with protein sorting and translation, cellular disassembly, RNA transport, DNA and RNA metabolism, and GPCR signaling

doi:10.1037/emo0001268

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