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39:198-205 [PubMed: 26285584] 52

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We found that higher HbA 1c was associated with a lower likelihood of marked weight reduction, consistent with a recent meta-analysis suggesting that hyperglycaemia may impact weight management [17]

Because the gastrointestinal tract rapidly degrades most plant-based peptide mimetics, and the article notes oral bioavailability data for these products is rarely published