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An increased risk of amputations was reported in the CANVAS Program trial but has not been demonstrated in any other clinical trial nor was there any signal of this issue in a meta-analysis involving 57,713 participants [54]

AID (or hybrid closed loop) systems consist of an insulin pump and continuous glucose monitor (CGM) that are connected via an algorithm to automatically adjust insulin delivery based on blood glucose levels

et al, 2018

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Utilization of Swertia Chirayita Plant Extracts for Management of Diabetes and Associated Disorders: Present Status, Future Prospects and Limitations

Semaglutide, a novel GLP-1 receptor agonist, in patients with type 2 diabetes and obesity: A systematic review and meta-analysis