Non-selective NSAIDs (aspirin, naproxen [e.g., Aleve], ibuprofen [e.g., Advil], diclofenac [e.g., Cambia], and indomethacin [Indocin]) inhibit the activity of both COX enzymes (Conaghan 2012)
The effects may also may vary by individual
Sometimes the issue is dosage, sometimes timing, and sometimes dietary factors that can be adjusted
These findings contribute to the growing body of literature suggesting that GLP-1based therapies may have applications beyond glycemic control, particularly in the context of hypogonadism related to obesity and insulin resistance
In contrast, a recent large registry cohort study by Ueda et al., which utilized data from nationwide registers in Sweden, Denmark, and Norway, found no difference in the risk of intestinal obstruction when comparing GLP-1RAs to SGLT2 inhibitors among over 300,000 patients [16]
GLP-1 medications have proven to be an effective tool to help patients manage their weight