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Transgenic mice specifically overexpressing IGF-1 in mammary epithelium demonstrate upregulation of the Vascular Endothelial Growth Factor (VEGF), a pro-angiogenic factor, in prepubertal glands and induction of cyclooxygenase-2 (COX-2), an inflammatory molecule that is also associated with angiogenesis and is responsible for formation of prostaglandin (PG), [55]

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Funding This study was supported by the National Natural Science Foundation of China to QZ (No.32270407) and the open fund of State Key Laboratory of Southwestern Chinese Medicine Resources (No.SCMR202103) and Natural Science Foundation of Sichuan (No.2022NSFSC0583) to JL

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