[19] Pre-existing significant gastrointestinal motility disorders (such as severe gastroparesis) warrant caution with GLP-1 medications
Clinical Context from Trials Pivotal trials showed low pancreatitis rates: STEP trials (semaglutide) had 0.1-0.2% events vs
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Braissant O, Foufelle F, Scotto C, Daua M, Wahli W: Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat