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Methods accounting for differences in randomization ratios and study-level cardiovascular risk Due to the asymmetric randomization ratios and patient populations with different cardiovascular risk across the trials, the crude estimates simply aggregating the trials on each of the pooled tirzepatide group and the pooled comparator group could be misleading

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nine were sub-studies or post hoc analyses of an included trial, while the remaining eight did not report the outcomes of interest (Supplemental Table S1)