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Phase II human trials of thymosin beta-4 (TB-500's parent molecule) have been conducted examining tissue repair rates, with studies reporting acceleration of repair in patients with pressure ulcers, stasis ulcers, and epidermolysis bullosa wounds, though detailed results remain limited in peer-reviewed literature

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Indeed, nNOS induction has been noted with a 6 day sleep deprivation protocol in mice (Hu et al., 1994

doi: 10.3390/ijms22094861 32 ChatawayJ.WilliamsT.LiV.MarrieR