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In this context, recognition of SAGE-DM may have practical implications by encouraging clinicians to consider alternative therapeutic priorities, including preservation of muscle mass, avoidance of overtreatment, correction of hormonal and nutritional imbalances, and individualized metabolic targets

Noticeable body-composition changes typically require 6 to 8 weeks, with optimal results over 3 to 6 months

However, results of recent early-stage clinical trials indicate GKAs lose their efficacy after several months of use

PLGA-based nanoparticles can cross the BBB by active processes namely receptor-mediated transcytosis (RMT) and carrier-mediated transport (CMT)

Below are evidence-based protocols for each compound, as well as a transition protocol for researchers moving between them

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