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Both prescription medications are classified as controlled substances, so they both are stringently monitored and come with the risk of abuse and physical or psychological dependence

Semaglutide is a GLP-1 receptor agonist that regulates blood sugar and slows digestion to promote fullness

The individual side effect rates (nausea, vomiting, diarrhea) are similar between the two compounds, but the discontinuation rate, which reflects how many people find the side effects intolerable, is significantly lower for semaglutide (5-7%) compared to retatrutide (12-18%)

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Lifestyle Changes Simple lifestyle changes can also make a difference