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That absence of data is not the same as a clean bill of health, and it's the reason a personal or family history of hormone-sensitive cancer (breast, prostate, colorectal) is one of the clearest contraindications for this compound rather than a discussion topic
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In high-fat diet-induced obesity models, the GPER agonist G1 reduces body weight and improves insulin sensitivity, highlighting its endocrine-mediated metabolic role [31, 74]