Several compounds with reduced internalization exhibited improved insulinotropic efficacy vs
In one 2023 study funded by Novo Nordisk, scientists found that participants without type 2 diabetes who took oral semaglutide every day for 68 weeks lost an average of 15 percent of their body weight
Diabetologia 59(7):14121421 Tonneijck L, Muskiet MHA, Smits MM, Hoekstra T, Kramer MHH, Danser AHJ et al (2017) Postprandial renal haemodynamic effect of lixisenatide vs once-daily insulin-glulisine in patients with type 2 diabetes on insulin-glargine: an 8-week, randomised, open-label trial
Kola B, Wittman G, Bodnar I, Amin F, Lim CT, Olah M, Christ-Crain M, Lolli F, van Thuijl H, Leontiou CA, Fuzesi T, Dalino P, Isidori AM, Harvey-White J, Kunos G, Nagy GM, Grossman AB, Fekete C, Korbonits M
Let the water trickle down the glass wall
Preprint at medRxiv (2023)