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VX-150 induces analgesia without compromising subject safety in a phase 1 study

This cascade mediates the production of inositol 1,4,5-trisphosphate (IP 3 ), which stimulates calcium (Ca 2+ ) release from the sarcoplasmic reticulum, and diacylglycerol (DAG), which activates protein kinase C (PKC)

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