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However, their use in the perioperative period surrounding major surgeries, like total joint arthroplasty (TJA), remains an area of growing interest and concern

Additional reporting by Jonathan Stempel and Christy Santhoshediting by Caroline Humer, Nia Williams and Susan Fenton)

Combining medication with basic healthy behaviors amplifies results

In a substudy of people with fatty liver disease (MASLD): 12 mg dose: 86% reduction in liver fat at 48 weeks 8 mg dose: 81-82% reduction in liver fat This is huge for people with type 2 diabetes, because 5-7% of people with diabetes develop fatty liver disease and liver fibrosis

Clinical studies show patients on GLP-1 medications can lose 15-20% of their body weight over 12-18 months when combined with lifestyle modifications

While the test primarily assesses GLP-1 receptor, GIPR, FTO, and MC4R variants related to medication response, understanding your broader metabolic profileincluding factors like inflammation and glucose regulationmay inform your provider's injection strategy and timeline adjustments