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Unlike Contrave, Wegovy comes as a weekly subcutaneous (under the skin) injection

Importantly, the ECD of GLP-1R undergoes a remarkable orientation change from the closed TMD-interacting conformation to the extended active conformation during peptide binding and activation

Based on target indication, the obesity segment held the largest GLP-1 drugs market share in 2025

FYI: Retatrutide is also being studied as a type 2 diabetes treatment, where it's shown impressive results for both blood sugar control and weight loss

References: (1) Gentinetta, S., et al

Lower intensity does not necessarily mean sufficient treatment