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Spires-Jones told the Science Media Centre

Most patients experience dramatic relief within the first month, though individual timelines vary based on dose escalation speed and personal metabolism

These data suggest that the 6-hydroxy-FAD-containing FSP1 is a catalytically active enzyme, and its NAD(P)H oxidation activity is higher than that of FAD-containing FSP1, which may also explain that the initial reaction rate of hFSP1 with more 6-hydroxy-FAD was clearly faster than that of cFSP1 with less 6-hydroxy-FAD (Supplementary Fig

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This process is remarkably similar to anti-angiogenic therapies used in oncology to starve tumors