Protein- and diabetes-induced glomerular hyperfiltration: role of glucagon, vasopressin, and urea
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In this trial, a fixed dose combination of once-weekly subcutaneous cagrilintide and semaglutide (a different approach to the unimolecular co-agonists tirzepatide, cotadutide and retatrutide) elicited impressive reductions in HbA 1 c and body weight over a short period in people with obesity and T2DM
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Released rapidly in response to nutrient ingestion, especially carbohydrates and fats, it enhances insulin secretion from pancreatic beta cells in a glucose-dependent manner, effectively lowering postprandial blood glucose without risking hypoglycemia