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Mitochondrial fission regulates germ cell differentiation by suppressing ROS-mediated activation of epidermal growth factor signaling in the drosophila larval testis

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Although the structure of the CBSCH004 complex has not yet been reported, Q222A mutation largely abolishes the inhibitory activity of CH004, suggesting that Gln222 is a key residue for its binding

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These include pancreatitis (rare but reported in clinical trials and post-marketing surveillance), gallbladder disease, and acute kidney injury (particularly in the setting of severe dehydration from gastrointestinal effects)