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To address the extremely short half-life (2 min) of native human GLP-1, structural modifications have been applied to GLP-1 RAs and a dual GLP-1/GIP RA
A 'Retatrutide trip' is only worthwhile if a specific approved study program exists there
With the surge in interest in weight loss drugs, doctors have also emphasized the potential risks of their use, including a higher risk of thyroid cancer with long-term use
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Research design note: Studies investigating body composition changes should specify whether the primary endpoint is total weight, fat mass, lean mass, or waist circumference, as the compounds differ most clearly on total and adipose-specific outcomes
