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GLP-1 receptor agonists work by mimicking the action of endogenous GLP-1, a hormone that stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways

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Synthetic GLP-1 agonists activate GLP-1 receptors in the pancreas , increasing cyclic adenosine monophosphate (cAMP)