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This approval is based on robust evidence from the SOUL cardiovascular outcomes trial, which demonstrated that oral semaglutide significantly lowers cardiovascular risk, even in patients who have not previously experienced a cardiovascular event

In patients with MTHFR gene variants (present in 4060% of the population), this conversion is less efficient, which can lead to temporary elevation in homocysteine and the nausea or digestive discomfort users report

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Monitoring is generally unnecessary for those taking standard supplements

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