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If a vial has been left at room temperature for an unknown duration, treat that as a documentation failure and discard it rather than guessing

Pharmacologically, only short-acting GLP-1RAs demonstrate a marked reduction in gastric emptying (156), while chronic activation of GLP-1R results in a waning effect on gastric emptying due to tachyphylaxis

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As in the other studies, adverse events mostly occurred during dose escalation