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Similarly, kefir improved hepatic steatosis in obese mice by modulating intestinal permeability and cecum propionate, mediated by Lactobacillus kefiri and prebiotics such as catechin-rich wine grape seed flour (Kwon et al., 2019)

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Moreover, the AP, which is situated in the caudal brainstem and is part of the dorsal vagal complex (DVC), which also includes the nucleus of the solitary tract (NTS) and the dorsal motor nucleus of the vagus (DMV), acts as a critical nucleus where peripheral ghrelin transmits orexigenic messages