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Methods Data were derived from the cohort of the study Childhood Health, Activity, and Motor Performance School Study Denmark (CHAMPS study DK) including 485 school children without metabolic syndrome

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This was the first cardiovascular outcomes trial in obesity (rather than diabetes) and established GLP-1 agonist benefit independent of glucose-lowering effects

However, humans have a different biological makeup and far fewer receptors for this medication in those specific thyroid cells