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ApoE-coated liposomal formulation is optimized using the Box-Behnken design (BBD)

Antidepressants classified as SSRI, SNRI or TCA are most common

These effects are often dose- or format-related

Its ability to cross cellular membranes and interact with various molecular targets makes it potent in managing oxidative stress and inflammatory responses

Giuseppe Giannini, [email protected], [email protected] These authors have contributed equally to this work ORCID: Giuseppe Giannini, orcid.org/0000-0002-7127-985X

To identify compounds exerting senolytic effects via the DDR-related cell fate pathway, we screened 80 molecules with defined inhibitory effects on DDR-related kinases