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Sleep and stress management Poor sleep amplifies pain perception through multiple mechanisms, including increased cortisol, reduced endogenous opioid activity, and impaired glymphatic clearance of inflammatory mediators

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These findings, together with the convenience of oncedaily oral dosing and onceweekly injection, support the use of these medications in this prediabetic population. Karen Elkind-Hirsch Elkind-Hirsch and colleagues recruited 119 premenopausal women aged 18 to 45 years with obesity and PCOS and without diabetes to participate in the study