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In pancreatic stellate cells under hypoxic conditions, melatonin induces apoptosis, modifies cyclin expressions, and initiates phosphorylation of MAPK, thereby reducing the viability of stellate and pancreatic cancer cells, and subsequently, impacting the tumor microenvironment and tumor progression [81]

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GLP-1 and the Primary Hallmarks of Aging In looking first at the primary hallmarks, evidence remains limited on how GLP-1s influence these specific hallmarks

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CJC-1295 is a synthetic analogue of growth hormone releasing hormone, or GHRH