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Shohag H, Ullah A, Qusar S, Rahman M, Hasnat A

Severe congestive heart failure (New York Heart Association Class III or IV): Semaglutide can affect heart function in susceptible patients

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For instance, someone who was less sexually active before starting tirzepatide and becomes more active as they lose weight and gain confidence may encounter UTI risk factors they had not previously needed to manage

Maximum: Up to roughly 4.5 mg weekly in advanced protocols, the dose tied to the greatest weight loss in early trials [4]

At the same time, manufacturers continue to face persistent supplychain constraints