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Similarly, miR-320a targets essential mitochondrial proteins including Cox8a and ATP5b, reducing oxidative phosphorylation efficiency and impairing sperm motility (57)

In contrast, caspase-1-mediated GSDMD cleavage can trigger tissue necrosis cascades in ischemiareperfusion injury [163]

In addition, Anti-apoptotic effect of silymarin against UV irradiation has been revealed by up-regulation of tumor-suppressor genes p53- and p21CIP1 (4,36)

Several studies have shown similar (Holmberg et al., 2003