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Chan School of Public Health)

While TTR-V30M carriers in the Portuguese, Brazilian, and Japanese populations share a common ancestral origin, the same mutation in Sweden has arisen independently [8]

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This is not surprising taking into account the highly flexible nature of IDPs/IDRs, which are best described as a protein clouds, and the fact that the utilized ensemble low-resolution techniques measure signals representing an average of all the states present in the conformational ensemble, and thereby conceal information about individual structures and their specific features

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