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For example, research published in peer-reviewed journals has shown that ispaghula can enhance GLP-1 secretion in both healthy individuals and those with type 2 diabetes, though the magnitude of the effect varies

There is also uncertainty over the long-term effects of GLP-1 receptor agonists for weight management in those without diabetes

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Conclusions The potential mechanisms of NAC's beneficial actions have been investigated in several in vitro and in vivo studies

Proceedings of the National Academy of Sciences, USA 110, 95599564