Agonist-Selective Tolerance The distinct agonist-selective mechanisms of MOR regulation of desensitization, endocytosis, and tolerance discussed above (Sections IV to VI) suggest that opioid agonists with improved tolerance liability could be developed
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It should be noted, however, that inhibition of p38 MAPK in mouse locus coeruleus neurons blocked neither desensitization nor endocytosis of MOR but did increase the rate of recovery from desensitization (Arttamangkul et al., 2012)
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There is also some evidence, such as asymmetric cross-tolerance (Pasternak, 2001) and tolerance-rescue studies (He et al., 2002), to suggest that mechanisms of tolerance may differ for different types of agonist
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